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Guesthouse Serafino

★★★★ Via Giovanni Vitelleschi 42, Rome, IT

9.4 guest rating· 299 reviews

About this hotel

Luxurious Rooms with Antique Furniture

Guesthouse Serafino in Rome's Prati district offers elegant rooms with high ceilings, antique furniture, and free Wi-Fi. The bright and colorful rooms are air-conditioned and feature private bathrooms.

Convenient Amenities

Guests can enjoy the convenience of a shared washing machine available in the afternoons. The hotel's proximity to the Tiber River and Via Cola di Rienzo shopping street adds to the overall comfort of the stay.

Prime Location

Located between Vatican City and Castle Sant'Angelo, this guesthouse is a short walk from St. Peter's Square and the Vatican Museums. With excellent bus links and the Ottaviano Metro Station nearby, exploring Rome is effortless. Book your stay at Guesthouse Serafino for a memorable Roman holiday.

Rooms & rates

Triple Room

Sleeps 3 · 21 m² · Sofa bed, Queen bed

  • Desk
  • Air conditioning
  • Single-room air conditioning for guest accommodation
  • Private bathroom
  • Emergency cord in bathroom

Double Room

Sleeps 2 · 15 m² · Queen bed

  • Desk
  • Air conditioning
  • Single-room air conditioning for guest accommodation
  • Private bathroom
  • Emergency cord in bathroom

Amenities

  • Free WiFi
  • Air conditioning
  • Non-smoking rooms
  • Non-smoking throughout
  • Family rooms
  • Cashless payment available
  • Cleaning standards that are effective against Coronavirus
  • Contactless check-in/check-out
  • Face masks for guests available
  • First aid kit available
  • Fruits
  • Guest room sealed after cleaning
  • Guest rooms disinfected between stays
  • Guests can opt-out any cleaning services during stay
Show all 23 amenities
  • Hand sanitizer in guest room and key areas
  • Heating
  • Invoice provided
  • Laundry washed per local authority guidelines
  • Lift / Elevator
  • Physical distancing rules followed
  • Shared stationery like menus, pens are removed
  • Staff adhere to local safety protocols
  • Walking tours

Location

What guests say9.4299 reviews

+ Great location+ Clean and comfortable rooms− Noise from the street− Basic amenities
Cleanliness9.3
Service10.0
Location10.0
Room Quality9.3
Amenities8.8
Value for Money9.3

Guest review

10.0

The room was very clean, comfortable, and short walking distance from multiple must see areas (Vatican, Castello Sant' Angelo), and walking distance from other (Trevi, Partheon). Buses are close by for other adventures. Staff was super helpful and available when we had cocerns.

Minerva · US · 2026-10-27

Guest review

10.0

Centraal gelegen

Cherith · NL · 2026-10-20

Förfärligt

3.0

Inget speciellt

− Blev totalt vilseförd. Ett nedgånget AirBnB med massor av gäster som något kollektiv

Jon · SE · 2026-10-15

Guest review

10.0

The location of this property is excellent! It’s conveniently located within walking distance of the Vatican, nightlife, the metro, and the airport shuttle, making it easy to explore Rome and visit many of its attractions. The staff was very friendly and accommodating. Marco welcomed us warmly and took the time to explain everything about the property and the surrounding area. He also shared wonderful recommendations on places to visit, things to see, and where to eat during our stay. We really appreciated his hospitality and helpful advice!

Oleksandra · US · 2026-10-10

Great location, amazing stay!

10.0

I've stayed here before a few years ago when they just started operating and honestly, they've stayed consistent as a great accomodation for travellers. The location is a few mins walk away from the Vatican and is surrounded by great dining in the Prati area!

Marie · AU · 2026-10-07

Pişman olmazsınız.

9.0

Çok temizdi, oda yüksek tavanlı ve rahattı. Asansörü vardı, ortak alanda 24 saat kahve içilebilecek makine vardı. Konumu da güzeldi. Haavalanı otobüsüne, metroya yakındı. Biz her yere yürüdük.

− Beğenmediğim bir şey olmadı.

Ayşegül · TR · 2026-09-09

Good to know

Please note that a surcharge applies for arrivals after check-in hours:

-EUR 50 from 21:00 to 22:00

after 23.00 property does not accept any check in .

Please note that rooms are cleaned every 4 days. This property does not accommodate bachelor(ette) or similar parties.

A deposit may be required at the property.